A recently developed system for switching on the activity of genes could improve treatments for a broad range of neurological diseases. Esteban Engel, a researcher in viral neuroengineering in the Princeton Neuroscience Institute, and his team have developed new gene promoters – which act like switches to turn on gene expression – that promise to broaden the ability to deliver large genes and keep them active for long periods of time.
Dr. Susan White and her genetics team treated two triplets from a family who had an undiagnosed neurodegenerative disorder in 2014. After one year of age, the children’s developmental skills declined. They lost visual coordination. Feeding and swallowing food became impossible. The children developed intractable seizures.
Researchers have found that amyloid, the protein that forms toxic aggregates, or clumps in the brain and is thought to be involved in the onset of Alzheimer’s disease (AD), accumulates faster in people with subtle cognitive difficulties compared with cognitively normal people.
For the first time, an intervention – lifting weights – has been able to slow and even halt degeneration, over a long period, in brain areas particularly vulnerable to Alzheimer’s disease.
There has long been a suspected link between neurological diseases and brain damage. Given the immediate symptoms of a head injury include several symptoms such as confusion and memory loss which are also observed in those affected by dementia, it does seem likely that the two share neurological underpinnings. Those who incur a head injury may exhibit such symptoms temporarily, or permanently, depending on the severity of the brain injury (Graff-Radford, 2019).
Now, research from the professional sports world may be helping to reveal and clarify the specific interactions between these two associated conditions.
Despite the fact that the signs of this combination can be confusing, the double diagnosis of Parkinson’s and dementia impacts a large number of people. Of the one million people who have Parkinson’s in the U.S., 50 to 80 percent may have dementia—either as a result of Parkinson’s pathology, or separately.
Physical activity may help to protect brain regions that are sensitive to neurodegeneration, according to new research in NeuroImage: Clinical that examined cognitive decline in the elderly.